Paul Teesdale Spittle

Courses

Teaching in 2018

Personal Bio

PhD | BSc

Research interests

My research is primarily focused on the design, synthesis and evaluation of compounds for the treatment of cancer and parasite infection. To this end, I make use of computational techniques (including molecular modelling of ligand-target interactions and structure activity relationship analysis), chemical synthesis (by solution and solid phase techniques, including parallel combinatorial synthesis), and in vitro assays.

Current projects involve inhibitors of glutathione S-transferase enzymes as antiparasitic agents, peloruside and its analogues and bioreducible anthraquinone N-oxide topoisomerase inhibitors as anticancer agents. I am also interested in understanding and harnessing WW domains, which are associated with protein recognition and binding.

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Publications

A.M Campbell, E.Liebau, J. Barrett, P.M. Brophy, P.H. Teesdale-Spittle and M. Wang. Towards validation of glutathione S-transferase as a nematode drug target. Chem.-Biol. Interact. 2001, 133, 240-243.

Gaitanos TN, Buey RM, Diaz JF, Northcote PT, Teesdale-Spittle P, Andreu JM, Miller JH. Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines. Cancer Research 2004, 64, 5063-5067.

Bordeleau ME, Matthews J, Wojnar JM, Lindqvist L, Novac O, Jankowsky E, Sonenberg N, Northcote P, Teesdale-Spittle P, Pelletier J. Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc. Natl. Acad. Sci U.S.A. 2005, 102,10460-10465.

Casey E.M., Teesdale-Spittle P. and Harvey J.E. Synthesis of the C12-C24 fragment of peloruside A by silyl-tethered diastereomer-discriminating RCM. Tetrahedron Lett 2008, 49, 7021–7023.

Batchelor R, Harvey JE, Northcote PT, Teesdale-Spittle P, and Hoberg JO. Heptanosides from Galactose-Derived Oxepenes via Stereoselective Addition Reactions. J. Org. Chem. 2009, 74, 7627–7632.

View more publications at ResearchGate

Courses

Teaching in 2018