School of Chemical and Physical Sciences

Publications

2013

J. W. Blunt, B. R. Copp, R. A. Keyzers, M. H. G. Munro and M. R. Prinsep “Marine natural products.” Nat. Prod. Rep. 2013, 30¸ 237-323.


2012

G.W. Carlile, R.A. Keyzers, K. A Teske, R. Robert, D.E. Williams, R.G. Linington, C.A. Gray, R.M. Centko, L. Yan, S.M. Anjos, H.M. Sampson, D. Zhang, J. Liao, J.W. Hanrahan, R.J. Andersen and D.Y. Thomas, “Correction of F580del-CFTR trafficking by the sponge alkaloid Latonduine is modulated by interaction with PARP”, Chemistry & Biology, 2012, 19, 1288-1299.

J.K. Gallaher, E.J. Aitken, R.A. Keyzers and J.M. Hodgkiss “Controlled aggregation of peptide-substituted perylene-bisimides”, Chem. Commun., 2012, 48, 7961-7963.

E. G. Dennis, R. A. Keyzers, C. M. Kalua, S. M. Maffei, E. L. Nicholson and P. K. Boss “Grape contribution to wine aroma: Production of hexyl acetate, octyl acetate and benzyl acetate during yeast fermentation is dependent upon precursors in the must”, J. Agric. Food Chem., 2012, 60, 2638-2646..

P. G. K. Clark, M. Lein and R. A. Keyzers “Studies of the H-D exchange mechanism of malonganenone B.” Org. Biomol. Chem., 2012, 10, 1725-1729.

J. W. Blunt, B. R. Copp, R. A. Keyzers, M. H. G. Munro and M. R. Prinsep “Marine natural products.” Nat. Prod. Rep. 2012, 29¸144-222.

V. Venturi, C. Davies, A. J. Singh, J. H. Matthews, D. S. Bellows, P. T. Northcote, R. A. Keyzers, and P. H. Teesdale-Spittle “The protein synthesis inhibitors mycalamides A and E have limited susceptibility toward the drug efflux network.” J. Biochem. Mol. Toxicol., 2012, 26, 94-100.


2011

I.L. Cockburn, E.-R. Pesce, J.M. Pryzborski, M.T. Davies-Coleman, P.G.K. Clark, R.A. Keyzers, L.L. Stephens and G.L. Blatch “Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: Inhibition of the plasmodial chaperone PfHsp70-1.” Biol. Chem., 2011, 392, 431-438.

R.A. Keyzers “From vine to wine: Grape-derived flavour and aroma in wine” Chem. Ed NZ, 2011, 124, 2-7.


2010

R.A. Keyzers and P.K. Boss. Changes in volatile production in fermentations made from musts with increasing grape content. J. Agric. Food Chem., 2010, 58, 1153-1164.

J.D. Dunlevy, K.L. Soole, M.V. Perkins, E.G. Dennis, R.A. Keyzers, C.M. Kalua and P.K. Boss. Two grape O-methyltransferases involved in the biosynthesis of methoxypyrazines: grape-derived aroma compounds important to wine flavour. Plant Mol. Biol., 2010, 74, 77-89.

C. Bottcher, R.A. Keyzers, P.K. Boss and C. Davies. Sequestration of auxin by the indole-3-acetic acid-amido synthetase GH3-1 in grape (Vitis vinifera) and the proposed role of auxin conjugation during ripening. J. Exp. Bot., 2010, 61, 3615-3625.


2009

C. Young, P. Truman, R.A. Keyzers, P. Northcote and T.W. Jordan. The Algal Metabolite Yessotoxin Affects Heterogenous Nuclear Ribonucleoproteins in HepG2 Cells. Proteomics, 2009, 9, 2529-2542.


2008

R.A. Keyzers, J. Daoust, M.T. Davies-Coleman, R. van Soest, A. Balgi, E. Donohue, M. Roberge and R.J. Andersen. Autophagy-Modulating Aminosteroids Isolated from the Sponge Cliona celata. Org. Lett., 2008, 10, 2959-2962.


2007

G.W. Carlile, R.A. Keyzers, K.A. Teske, R. Robert, D.E. Williams, R. Linington, C.A. Gray, J. Hanrahan, R.J. Andersen, D.Y. Thomas. Correction of Delta F508 CFTR Trafficking Defect by a Novel Family of Marine Sponge Derived Alkaloids. Pediatr. Pulmonol., 2007, S. 30,  287.

DE. Williams, R.A. Keyzers, K. Warabi, K. Desjardine, J.L. Riffell, M. Roberge and R.J. Andersen. Spirastrellolides C to G: Macrolides Obtained from the Marine Sponge Spirastrella coccinea. J. Org. Chem., 2007, 72, 9842-9845.

C.E. Whibley, K.L. McPhail, R.A. Keyzers, M.F. Maritz, V.C. Leaner, M.J. Birrer, M.T. Davies-Coleman and D.T. Hendricks. Reactive Oxygen Species Mediated Apoptosis of Esophageal Cancer Cells  Induced by Marine triprenyl Toluquinones and Toluhydroquinones. Mol. Cancer Ther., 2007, 6,  2535-2543.


2006

R.A. Keyzers, P.T. Northcote and M.T. Davies-Coleman. Spongian Diterpenoids from Marine Sponges. Nat. Prod. Rep., 2006, 23, 321-334.


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2005

R.A. Keyzers, C.A. Gray, M.H. Schleyer, C.E. Whibley, D.T. Hendricks and M.T. Davies-Coleman. Malonganeones AC, Novel Tetraprenylated Alkaloids from the Mozambique Gorgonian Leptogorgia gilchristi. Tetrahedron, 2005, 62, 2200-2206.

M.T. Davies-Coleman, W. Froneman, R.A. Keyzers, C.E. Whibley, D. Hendricks, T. Samaai, C. McQuaid. Anti-Oesophageal Cancer Activity of Deep-Water Marion Island Sponges. S.Afr. J. Sci., 2005, 101, 489-490.

C.E. Whibley, R.A. Keyzers, A.G. Soper, M.T. Davies-Coleman, T. Samaai, and D.T. Hendricks. Antiesophageal Cancer Activity from Southern African Marine Organisms. Ann. N. Y. Acad. Sci., 2005, 1056, 405-412.

P. Truman, R.A. Keyzers, P.T. Northcote, V. Ambrose, N.A. Redshaw, and F.H. Chang. Lipophillic Toxicity from the Marine Dinoflagellate Karenia brevisulcata. Toxicon, 2005, 46, 441-445.

A.W.W. van Wyk, C.A. Gray, R.A. Keyzers, D.E.A. Rivett, M.R. Caira, B.S. Nader, G.E. Davis, T.L. Werk and M.T. Davies-Coleman. Transformations of Hispanolone. Novel Michael Adducts with In Vivo Activity Against Rice Blast (Pyricularia oryzae). Tetrahedron, 2005, 61, 8493-8498.

R.A. Keyzers, C.E. Arendse, D.T. Hendricks, T. Samaai and M.T. Davies-Coleman. New Makaluvic Acids from the South African Latrunculid Sponge Strongylodesma aliwaliensis. J. Nat. Prod., 2005, 68, 506-510.

R.A. Keyzers and M.T. Davies-Coleman. Anti-inflammatory Metabolites from Marine Sponges. Chem. Soc. Rev., 2005, 34, 355-365.


2004 and previous

R.A. Keyzers, T. Samaai and M.T. Davies-Coleman. Novel Pyrroloquinoline Ribosides from the South African Latrunculid Sponge Strongylodesma aliwaliensis. Tetrahedron Lett., 2004, 45, 9415-9418.  

T. Samaai, R.A. Keyzers and M.T. Davies-Coleman. A New Species of Strongylodesma Levi, 1969 (Porifera; Demospongiae; Poecilosclerida; Latrunculiidae) from Aliwal Shoal on the East Coast of South Africa. Zootaxa, 2004, 584, 1-11.

R.A. Keyzers, P.T. Northcote and O.A. Zubkov. Novel Anti-Inflammatory Spongian Diterpenes from the New Zealand Marine Sponge Chelonaplysilla violacea. Eur. J. Org. Chem., 2004, 419-425.

R.A. Keyzers, P.T. Northcote and M.V. Berridge. Clathriol B, a New 14b Marine Sterol from the New Zealand Sponge Clathria lissosclera.  Aust. J. Chem., 2003, 56, 279-282.

R.A. Keyzers, P.T. Northcote and V. Webb. Clathriol: An Anti-inflammatory Polyoxygenated Marine Sterol with the Rare 14b Stereochemistry. J. Nat. Prod., 2002,  65,  598-600.


Patents

Latonduine-related compound correctors of D F508 CFTR trafficking. R.J. Andersen, R.A. Keyzers, C.A. Gray, D.Y. Thomas, J.W. Hanrahan, and G.W. Carlile,  2009, WO  2009003289.

Algal Toxin.  F.H. Chang, A.L. Mackenzie, P.T. Northcote, R.A. Keyzers and P. Truman, 2001, WO 2001029186.


Book Chapters

J.D. Dunlevy, C.M. Kalua, R.A. Keyzers and P.K. Boss. The Production of Flavour and Aroma Compounds in Grape Berries, in Grapevine Molecular Physiology and Biotechnology 2nd ed, K.A. Roubelakis-Angelakis (ed.) Springer Science+Business Media, 2009.

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