Publications Paul Teesdalespittle

Pors K, Shnyder SD, Teesdale-Spittle PH, Hartley JA, Zloh M, Searcey M, Patterson LH. Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: Potential for development of tumor-selective N-oxides. J. Med. Chem. 2006, 49, 7013-7023.

Casey EM, Teesdale-Spittle P and Harvey JE Synthesis of the C12-C24 fragment of peloruside A by silyl-tethered diastereomer-discriminating RCM. Tetrahedron Lett 2008, 49, 7021–7023.

Teesdale-Spittle P. In Search of Biological Activity. Chemistry in New Zealand 2008, 72, 138-143.

Baird LJ, Timmer MSA, Teesdale-Spittle PH and Harvey JE. Total Synthesis of Aigialomycin D Using a Ramberg-Backlund/RCM Strategy. J. Org. Chem. 2009, 74, 2271-2277.

Batchelor R, Harvey JE, Northcote PT, Teesdale-Spittle P, and Hoberg JO. Heptanosides from Galactose-Derived Oxepenes via Stereoselective Addition Reactions. J. Org. Chem. 2009, 74, 7627–7632.

Batchelor R, Harvey JE, Teesdale-Spittle P, and Hoberg JO. Mechanistic studies of rearrangements during the ring-expansions of cyclopropanated carbohydrates. Tet. Lett. 2009, 50, 7283-7285.

Wiemuth D, Lott JS, Ly K, Ke Y, Teesdale-Spittle P, Snyder PM, McDonald FJ. Interaction of Serum- and Glucocorticoid regulated Kinase 1 (SGK1) with the WW domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS ONE 2010, 5(8): e12163. doi:10.1371/journal.pone.0012163

Singh AJ, Razzak M, Teesdale-Spittle P, Gaitanos TN, Wilmes A, Paterson I, Goodman J, Miller JH, Northcote PT. Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues. Org. Biomol. Chem. 2011, 9, 4456-4466.

Baird LJ, Colomban C, Turner C, Teesdale-Spittle PH and Harvey JE. Alkenylphosphonates: unexpected products from reactions of methyl 2-[(diethoxyphosphoryl)methyl]benzoate under Horner–Wadsworth–Emmons conditions. Org. Biomol. Chem., 2011, 9, 4432-4435.

Bordeleau ME, Matthews J, Wojnar JM, Lindqvist L, Novac O, Jankowsky E, Sonenberg N, Northcote P, Teesdale-Spittle P, Pelletier J. (2005) Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc. Natl. Acad. Sci U.S.A. 102,10460-10465.

Pors K, Plumb JA, Brown R, Teesdale-Spittle P, Searcey M, Smith PJ, Patterson LH. (2005) Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells J. Med. Chem. 48, 6690-6695.

Marquez N, Chappell SC, Sansom OJ, Clarke AR, Teesdale-Spittle P, Errington RJ and Smith PJ. (2004) Microtubule stress modifies intra-nuclear location of Msh2 in mouse embryonic fibroblasts. Cell Cycle, 3, 662-671.

Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor. Pors K., Paniwnyk Z., Ruparelia K.C. Teesdale-Spittle P.H., Hartley J.A., Kelland L.R., Patterson L.H. J. Med. Chem. (2004) 47, 1856-1859.

B.L. Stocker, P. Teesdale-Spittle P.H. and J.O. Hoberg. Studies on the Origin of 1,5-anti Induction in Boron-Mediated Aldol Reactions. Eur. J. Org. Chem. (2004) 330-336.

Van Rossum AJ, Jefferies JR, Rijsewijk FAM, LaCourse EJ, Teesdale-Spittle P, Barrett J, Tait A, Brophy PM. Binding of hematin by a new class of glutathione transferase from the blood-feeding parasitic nematode Haemonchus contortus . Infection and Immunity (2004) 72, 2780-2790.

Gaitanos TN, Buey RM, Diaz JF, Northcote PT, Teesdale-Spittle P, Andreu JM, Miller JH. (2004) Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines. Cancer Research 64, 5063-5067.

Pors K, Paniwnyk Z, Teesdale-Spittle P, Plumb JA, Willmore E, Austin CA, Patterson LH. (2003) Alchemix: A novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer. Mol. Cancer Ther. 2, 607-610.

J.S. Lott, S.J. Coddington-Lawson, P.H. Teesdale-Spittle, F.J. McDonald. (2002) A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel. Biochem. J. 361, 481-488.

Liebau E., Bergman, B., Campbel, A.M., Teesdale-Spittle, P.H., Brophy, P.M., Lüersen, K. and Walter, R.D. (2002) The glutathione S-transferase from Plasmodium falciparum [rapid communication]. Mol. Biochem. Parasitol. 124, 85-90