Dr Darren Day
Biochemistry, Molecular Biology
School of Biological Sciences
Phone: 04 463 6087
Location: Room 802, New Kirk Building, Kelburn Pde, Kelburn Campus
300 level: Genes and Genomes, BIOL340, (course coordinator)
300 level: Cellular Regulation, BMSC339, (course coordinator)
400 level: Human and Clinical Biochemistry, BMSC433, (course coordinator)
My laboratory's interests are focused on developing DNA aptamers for the treatment of human diseases. In particular we a investigating the use of aptamers for treating bacterial infections and as a means of restoring antibiotic sensitivity to multi-drug resistant bacterial strains. The emergence of bacterial strains that are resistant to multiple antibiotics is a major health concern that causes significant suffering. Many bacteria develop multi-drug resistance by pumping antibiotic out of the cells via efflux pumps found in their cell walls. Multi-drug resistance can be reversed by inhibiting the activity of these efflux pumps, however there are currently no suitable efflux pump inhibitors that can be used in humans. We are developing DNA aptamers to neutralise the efflux pumps to restore antibiotic sensitivity. We will target the bacteria that infect the wounds of diabetic patients and which also cause chronic infections in the lungs of cystic fibrosis patients. These bacteria are highly resistant to antibiotic treatment and cause significant suffering to New Zealanders.
Steel R, Day DJ. (2014) Increased apoptosis and secretion of tryptase by mast cells in infantile haemangioma treated with propranolol. Pathology. 46:496-500. doi:10.1097/PAT.0000000000000143.
Steel RWJ, Miller JH, Sim DA, *Day DJ. (2014) Delta-9-tetrahydrocannabinol disrupts hippocampal neuroplasticity and neurogenesis in trained, but no untrained adolescent Sprague-Dawley rats. Brain Res. http://dx.doi.org/10.1016/j.brainres.2013.12.034
Laing EL, Brasch HD, Steel R, Jia J, Itinteang T, Tan ST, *Day DJ. (2013) Verrucous hemangioma expresses primitive markers. J Cutan Pathol. 40:391-6
Itinteang T, Tan ST, Jia J, Steel R, Laing EL, Brasch HD, *Day DJ (2013) Mast cells in infantile haemangioma possess a primitive myeloid phenotype. J Clin Pathol. 66:597-600.
Itinteang T, Withers AHJ, Leadbitter P, Day DJ, Tan ST (2012) Letters REPLY: Pharmacologic therapies for infantile hemangioma: Is there a rational basis? Plastic Reconstruc Surg 129:725-726.
Itinteang T, Tan ST, Brasch HD, Steel R, Best HA, Vishvanath A, Jia J, *Day DJ. (2012) Infantile Haemangioma expresses embryonic stem cell markers. J Clin Path 65:394-398
Tan ST, Itinteang T, Day DJ, O'Donnell C, Mathy JA, Leadbitter P. (2012) Treatment of Infantile Haemangioma with Captopril. Br J Dermatol. 167:619-24.Itinteang T, Tan ST, Guthrie S, Tan CES, McIntyre BC Brasch H, Day DJ. A placental chorionic villous mesenchymal core cellular origin for infantile haemangioma. J Clin Pathol (2011). doi:10.1136/jclinpath-2011-200191
Vishvanath, A; Itinteang T, Tan ST, Day DJ. (2011) Infantile Hemangioma Expresses TRAIL, TRAIL receptors, osteoprotegerin and RANKL Histopathology. (In press)
Itinteang T, Tan ST, Brasch HD, Vishvanath A, Day DJ (2011) Primitive erythropoiesis in infantile haemangioma. Brit J Dermatol; 164: 1097-1100.
Itinteang T, Vishvanath, Day DJ, Tan ST (2011). Mesenchymal stem cells in infantile haemangioma. J Clin Pathol. 64:232-236.
Itinteang T, Withers AHJ, Leadbitter P, Day DJ, Tan ST (2011) Pharmacologic therapies for infantile haemangioma: Is there a relational basis? Plastic and Reconstructive Surgery, 128:499-507.
Steel RWT, Miller JH, Sim DA, Day DJ (2011) Learning Impairment by 9-Tetrahydrocannabinol in Adolescence is Attributable to Deficits in Chunking. Behav Pharmaco (In press).