Anne Camille La Flamme
Cellular immunology, immune regulation, disease processes, infectious diseases, autoimmunity
My primary research interest is in the immune regulation of disease. In particular, my research focuses on the pivotal role of one specific immune cell, the macrophage, in the regulation of pro-inflammatory diseases such as multiple sclerosis. These studies investigate the factors that regulate macrophage activation to induce or suppress disease. Recent work, in collaboration with other New Zealand and international researchers, is aimed at identifying new therapeutic targets and drugs to treat multiple sclerosis.
Additionally, I am investigating several aspects of schistosomiasis, a parasitic worm infection. This disease affects over 200 million people worldwide, and one of the applied goals of this research is to identify and develop biomarkers that predict the development of severe disease in patients. Finally, in partnership with other researchers in the Allan Wilson Centre, I am involved in elucidating the immune responses of tuatara.
Visit the Cell and Immunobiology web page.
Manivannan B, P Rawson, TW Jordan, DMS Karanja, P N M Mwinzi, W E Secor, and AC La Flamme. 2011. Identification of cytokeratin-18 as a biomarker of mouse and human hepatosplenic schistosomiasis. Infect. Immun. In press.
Slaney, CY, A Toker, AC La Flamme, BT Bäckström, and JL Harper. 2011. Naïve blood monocytes suppress T-cell function. A possible mechanism for protection from autoimmunity. Immunol. Cell Biol. 89:7-13.
La Flamme, AC, D de Thierry, S O’Neill, and H Miller. 2010. Toll-like receptor responses in tuatara. NZ J Zoology. 37: 235-42.
Manivannan, B, P Rawson, T.W Jordan, E Secor, and AC La Flamme. 2010. Differential patterns of liver proteins in experimental murine hepatosplenic schistosomiasis. Infect. Immun. 78:618-28.
Robinson, M J, F Ronchese, JH Miller, and AC La Flamme. 2010. Paclitaxel inhibits killing by murine cytotoxic T lymphocytes in vivo but not in vitro. Immunol. Cell Biol. 88:291-6.
Keating, P, D O’Sullivan, JB Tierney, D Kenwright, S Mirmoeini, L Mawasse, F Brombacher, and AC La Flamme. 2009. Protection from EAE by IL-4Ralpha-- macrophages depends upon T regulatory cell involvement. Immunol. Cell Biol. 87:534-45.
Crume, KP, D O’Sullivan, JH Miller, PT Northcote, and AC La Flamme. 2009. Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and peloruside A. J. Leuk. Biol. 86:949-58.
Tierney, JB, M Kharkrang, and AC La Flamme. 2009. Type II-activated macrophages suppress the development of experimental autoimmune encephalomyelitis. Immunol. Cell Biol. 87:235-40.